Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, member of Liverpool Health Partners, Liverpool, UK.
Liverpool Women's Hospital NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK.
Biol Reprod. 2023 Aug 10;109(2):125-136. doi: 10.1093/biolre/ioad062.
The fallopian tubes (FTs) are part of the female upper genital tract. The healthy FT provides the biological environment for successful fertilization and facilitates the subsequent movement of the conceptus to the endometrial cavity. However, when the FT is damaged, as with salpingitis, pyosalpinx, and hydrosalpinx, it may increase the risk of an ectopic pregnancy, a life-threatening condition. Decidualization refers to a multifactorial process by which the endometrium changes to permit blastocyst implantation. The decidualization reaction is vital for endometrial receptivity during the window of implantation. To date, no comprehensive review that collates evidence on decidualization in the human FT has been conducted. Therefore, the aim of this review is to compile the current evidence on cellular decidualization occurring in the healthy and pathological FT in women of reproductive age. A literature search was conducted using five databases and identified 746 articles, 24 of which were analyzed based on inclusion and exclusion criteria. The available evidence indicates that the FT are able to undergo decidual changes under specific circumstances; however, the exact mechanism by which this occurs is poorly understood. Further research is needed to elucidate the mechanism by which decidualization can occur in the FT.
输卵管（FTs）是女性上生殖道的一部分。健康的 FT 为成功受精提供了生物学环境，并有助于随后将胚胎移动到子宫内膜腔。然而，当 FT 受损时，如输卵管炎、脓性输卵管炎和输卵管积水，可能会增加异位妊娠的风险，这是一种危及生命的情况。蜕膜化是指子宫内膜发生变化以允许胚泡着床的多因素过程。蜕膜化反应对于着床窗口期的子宫内膜容受性至关重要。迄今为止，尚未进行过对人类 FT 中蜕膜化的综合证据进行整理的综述。因此，本综述的目的是编译关于生殖年龄妇女中健康和病理 FT 中发生的细胞蜕膜化的现有证据。使用五个数据库进行了文献检索，共确定了 746 篇文章，其中 24 篇根据纳入和排除标准进行了分析。现有证据表明，在特定情况下，FT 能够发生蜕膜变化；然而，其确切机制尚不清楚。需要进一步的研究来阐明 FT 中蜕膜化发生的机制。
