Poirier L A, Weisburger E K
J Natl Cancer Inst. 1979 Apr;62(4):833-40.
A list of 102 chemicals was prepared for subsequent mutagenesis assays in a National Cancer Institute program to determine the extent of correlation between carcinogenesis and mutagenesis in standardized assays. The chemicals were divided into five major categories: 37 aromatic amines, 11 polycyclic aromatic hydrocarbons, 8 nitrosamines and nitrosamides, 16 alkylating agents, and a miscellaneous category consisting of 11 heterocyclic compounds, 7 amides, ureas and acylating agents, 5 antimetabolites, 4 inorganic chemicals, and 3 promoters. The chemicals were further described as procarcinogens (requiring metabolic activation to exert their biologic activities), ultimate carcinogens (direct-acting chemicals not requiring metabolic activation), and noncarcinogens (compounds shown to be inactive in one or more adequate carcinogenicity tests). An extensive bibliography documents the selection and categorization of the compounds.
在国立癌症研究所的一个项目中，为后续的诱变试验准备了一份包含102种化学物质的清单，以确定标准化试验中致癌作用与诱变作用之间的关联程度。这些化学物质被分为五大类：37种芳香胺、11种多环芳烃、8种亚硝胺和亚硝酰胺、16种烷基化剂，以及一个杂类，包括11种杂环化合物、7种酰胺、脲和酰化剂、5种抗代谢物、4种无机化学物质和3种促癌剂。这些化学物质进一步被描述为前致癌物（需要代谢激活才能发挥其生物活性）、终致癌物（无需代谢激活的直接作用化学物质）和非致癌物（在一项或多项充分的致癌性试验中显示无活性的化合物）。一份详尽的参考文献记录了这些化合物的选择和分类。
