Chen Xiao-Wei, Hou Zi-Chao, Chen Chi, Zhang Ling-Hui, Chen Meng-En, Zhang Fu-Min
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 China
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University Shanghai 200062 China.
Chem Sci. 2023 May 2;14(21):5699-5704. doi: 10.1039/d3sc00582h. eCollection 2023 May 31.
The first enantioselective total syntheses of six natural and two proposed meroterpenoids isolated from have been achieved in 7-9 steps from 2-methylcyclohexanone. The current synthetic approaches feature a high level of synthetic flexibility, stereodivergent fashion and short synthetic route, thereby providing a potential platform for the preparation of numerous this-type meroterpenoids and their -natural products.
从2-甲基环己酮出发，通过7至9步反应实现了从[具体来源]中分离出的六种天然萜类化合物和两种假定的杂萜类化合物的首次对映选择性全合成。目前的合成方法具有高度的合成灵活性、立体发散性和较短的合成路线，从而为制备众多此类杂萜类化合物及其天然产物提供了一个潜在的平台。
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