Chen Lele, Chen Shuguang, Sun Peng, Liu Xinyue, Zhan Zhaoshuang, Wang Jiafeng
College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, No.4655 Daxue Road, Jinan, 250355, China.
Chin Med. 2023 Jan 10;18(1):4. doi: 10.1186/s13020-022-00704-6.
Psoralea corylifolia L. (PCL), referred to as "Bu-gu-zhi" in Chinese, has great medicinal values since ancient times. PCL is the dried ripe fruit of Psoralea corylifolia L., which has been widely used in traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency, enuresis and urinary frequency, chills and pain of the waist and knees, dawn diarrhea and vitiligo. In this paper, a systematic of the botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics of PCL was presented, along with future research directions. According to the results, PCL contains approximately 163 chemical components, including coumarins, flavonoids, monoterpene phenols, benzofurans, glycosides, lipids, fatty acids, and volatile oils. PCL and its active ingredients have a variety of pharmacological activities, such as anti-inflammatory, antibacterial, antiviral, antioxidant, antitumor, antiosteoporosis, cardioprotective, neuroprotective, and immunomodulatory. Further study of quality control standards and potential mechanisms of PCL is also needed. In addition, more toxicological studies will also contribute to the progress of clinical trials.
补骨脂，中药名为“补骨脂”，自古以来就具有很高的药用价值。补骨脂是豆科植物补骨脂的干燥成熟果实，在传统中医中广泛用于治疗肾阳不足、遗尿尿频、腰膝冷痛、五更泄泻及白癜风。本文对补骨脂的植物学、传统用途、植物化学、药理学、毒理学、质量控制和药代动力学进行了系统综述，并提出了未来的研究方向。结果表明，补骨脂含有约163种化学成分，包括香豆素、黄酮类、单萜酚类、苯并呋喃类、糖苷类、脂质、脂肪酸和挥发油。补骨脂及其活性成分具有多种药理活性，如抗炎、抗菌、抗病毒、抗氧化、抗肿瘤、抗骨质疏松、心脏保护、神经保护和免疫调节等。还需要进一步研究补骨脂的质量控制标准和潜在机制。此外，更多的毒理学研究也将有助于临床试验的进展。
