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日粮补充胆汁酸可调节高脂日粮喂养的鲤鱼（L.）的糖脂代谢及微生物群。

Dietary Bile Acid Supplementation Could Regulate the Glucose, Lipid Metabolism, and Microbiota of Common Carp ( L.) Fed with a High-Lipid Diet.

作者信息

Yang Liping, Liu Mingyu, Zhao Mengjuan, Zhi Shaoyang, Zhang Wenlei, Qu Leya, Xiong Jinrui, Yan Xiao, Qin Chaobin, Nie Guoxing, Wang Shengpeng

机构信息

College of Fisheries, Henan Normal University, No. 46 Jianshe Road, Xinxiang 453007, China.

Dezhou Key Laboratory for Applied Bile Acid Research, Shandong Longchang Animal Health Product Co., Ltd., Dezhou, China.

出版信息

Aquac Nutr. 2023 May 24;2023:9953927. doi: 10.1155/2023/9953927. eCollection 2023.

DOI:10.1155/2023/9953927
PMID:37266416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10232174/
Abstract

This study sought to examine the role of bile acids in the regulation of glucose and lipid metabolism, intestinal flora, and growth in high-fat diet-fed common carp ( L.). Fish (6.34 ± 0.07 g) were fed for 56 days with three different diets, the control diet (CO, 5.4% lipid), high-fat diet (HF, 11% lipid), and high-fat diet with 60 mg/kg bile acids (BAs, 11% lipid). The results showed that high-fat diets resulted in poor growth performance and increased triglyceride (TG) in serum and the liver. The addition of bile acids significantly alleviated the adverse effects of a high-fat diet. The mRNA expression results indicated that bile acids may improve lipid metabolism through the enhancement of the peroxisome proliferator-activated receptor (PPAR). The expression of gluconeogenesis-related phosphoenolpyruvate carboxykinase (PEPCK) mRNA was inhibited, while fibroblast growth factor 19 (FGF19) was significantly higher. Bile acids reshaped the intestinal microflora community, with the level of increasing. The correlation analysis indicated that , , and in the gut are associated with genes involved in glucose and lipid metabolism. These results indicated that bile acids could ameliorate the negative effects of high-fat diets on common carp.

摘要

本研究旨在探讨胆汁酸在高脂饲料喂养的鲤鱼（L.）的葡萄糖和脂质代谢调节、肠道菌群及生长方面所起的作用。将体重为（6.34±0.07克）的鱼用三种不同的饲料喂养56天，即对照饲料（CO，脂质含量5.4%）、高脂饲料（HF，脂质含量11%）和添加60毫克/千克胆汁酸的高脂饲料（BAs，脂质含量11%）。结果表明，高脂饲料导致生长性能不佳，血清和肝脏中的甘油三酯（TG）增加。添加胆汁酸显著减轻了高脂饲料的不利影响。mRNA表达结果表明，胆汁酸可能通过增强过氧化物酶体增殖物激活受体（PPAR）来改善脂质代谢。糖异生相关的磷酸烯醇式丙酮酸羧激酶（PEPCK）mRNA的表达受到抑制，而成纤维细胞生长因子19（FGF19）显著升高。胆汁酸重塑了肠道微生物群落， 水平升高。相关性分析表明，肠道中的 、 、 和 与参与葡萄糖和脂质代谢的基因有关。这些结果表明，胆汁酸可以改善高脂饲料对鲤鱼的负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/6e41e55be2f1/ANU2023-9953927.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/7a8e51cf5171/ANU2023-9953927.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/392baf90dbf3/ANU2023-9953927.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/cf24892365c1/ANU2023-9953927.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/3b6836d3082d/ANU2023-9953927.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/692324dd18c1/ANU2023-9953927.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/def427f30d26/ANU2023-9953927.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/db38b9aca557/ANU2023-9953927.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/6e41e55be2f1/ANU2023-9953927.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/7a8e51cf5171/ANU2023-9953927.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/392baf90dbf3/ANU2023-9953927.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/cf24892365c1/ANU2023-9953927.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/3b6836d3082d/ANU2023-9953927.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/692324dd18c1/ANU2023-9953927.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/def427f30d26/ANU2023-9953927.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/db38b9aca557/ANU2023-9953927.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f76e/10232174/6e41e55be2f1/ANU2023-9953927.008.jpg

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本文引用的文献

[1]
Effects of Genistein on Lipid Metabolism, Antioxidant Activity, and Immunity of Common Carp ( L.) Fed with High-Carbohydrate and High-Fat Diets.

Aquac Nutr. 2023-3-31

[2]
Metabolomic signatures for liver tissue and cecum contents in high-fat diet-induced obese mice based on UHPLC-Q-TOF/MS.

Nutr Metab (Lond). 2021-6-30

[3]
A high-fat diet and high-fat and high-cholesterol diet may affect glucose and lipid metabolism differentially through gut microbiota in mice.

Exp Anim. 2021-2-6

[4]
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes.

Gut. 2020-10

[5]
Dietary fatty acids and CD36-mediated cholesterol homeostasis: potential mechanisms.

Nutr Res Rev. 2021-6

[6]
Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet.

Front Endocrinol (Lausanne). 2018-9-27

[7]
Actinobacteria: A relevant minority for the maintenance of gut homeostasis.

Dig Liver Dis. 2018-3-5

[8]
Bile acids in glucose metabolism in health and disease.

J Exp Med. 2018-1-16

[9]
Bile acid metabolism and signaling in liver disease and therapy.

Liver Res. 2017-6

[10]
The effect of feeding high fat diet to beef cattle on manure composition and gaseous emission from a feedlot pen surface.

J Anim Sci Technol. 2016-6-10

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