Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Infection Prevention and Control, Renmin Hospital of Wuhan University, Wuhan, China.
Front Immunol. 2023 May 17;14:1152336. doi: 10.3389/fimmu.2023.1152336. eCollection 2023.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), the prime causes of morbidity and mortality in critically ill patients, are usually treated by general supportive treatments. Endoplasmic reticulum autophagy (ER-phagy) maintains cellular homeostasis by degrading damaged endoplasmic reticulum (ER) fragments and misfolded proteins. ER-phagy is crucial for maintaining ER homeostasis and improving the internal environment. ER-phagy has a particular role in some aspects, such as immunity, inflammation, cell death, pathogen infection, and collagen quality. In this review, we summarized the definition, epidemiology, and pathophysiology of ALI/ARDS and described the regulatory mechanisms and functions of ER-phagy as well as discussed the potential role of ER-phagy in ALI/ARDS from the perspectives of immunity, inflammation, apoptosis, pathogen infection, and fibrosis to provide a novel and effective target for improving the prognosis of ALI/ARDS.
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）是危重病患者发病率和死亡率的主要原因，通常采用一般支持性治疗。内质网自噬（ER-phagy）通过降解受损的内质网（ER）片段和错误折叠的蛋白质来维持细胞内稳态。ER-phagy 对于维持 ER 内稳态和改善内部环境至关重要。ER-phagy 在某些方面（如免疫、炎症、细胞死亡、病原体感染和胶原质量）具有特定作用。在这篇综述中，我们总结了 ALI/ARDS 的定义、流行病学和病理生理学，并描述了 ER-phagy 的调节机制和功能，从免疫、炎症、细胞凋亡、病原体感染和纤维化的角度讨论了 ER-phagy 在 ALI/ARDS 中的潜在作用，为改善 ALI/ARDS 的预后提供了一个新的有效靶点。
