Ghorbani Nejad Behnam, Rahimi Kakavandi Nader, Mirzaei Soheila, Rastegar Pouyani Nima, Habibian Sezavar Ahmad
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Department of Occupational Health Engineering, School of Health, Ilam University of Medical Sciences, Ilam, Iran.
Int J Environ Health Res. 2024 Mar;34(3):1443-1452. doi: 10.1080/09603123.2023.2219980. Epub 2023 Jun 2.
This meta-analysis evaluates the association between atrazine (ATR) exposure and small for gestational age (SGA), preterm birth (PTB), and low birth weight (LBW). A comprehensive search was done on academic databases (e.g. PubMed, Scopus, Embase, and Google Scholar) to achieve all pertinent studies up to May 2023. A pooled odd ratio (OR) and corresponding 95% confidence interval (CI) were applied to evaluate this correlation. As a result, five eligible studies met the inclusion criteria and were included in our study, and the result of the present meta-analysis showed that ATR exposure increased the risk of SGA (OR = 1.11; 95% CI = 1.03-1.20 for highest versus lowest category of ATR), PTB (OR = 1.16; 95% CI = 1.03-1.30), and LBW (OR = 1.26; 95% CI = 1.10-1.44). This meta-analysis suggests that ATR in drinking water may be a risk factor for SGA, PTB, and LBW.
本荟萃分析评估了阿特拉津（ATR）暴露与小于胎龄儿（SGA）、早产（PTB）和低出生体重（LBW）之间的关联。对学术数据库（如PubMed、Scopus、Embase和谷歌学术）进行了全面检索，以获取截至2023年5月的所有相关研究。采用合并比值比（OR）和相应的95%置信区间（CI）来评估这种相关性。结果，五项符合条件的研究满足纳入标准并被纳入我们的研究，本荟萃分析的结果表明，ATR暴露增加了SGA（最高与最低ATR类别相比，OR = 1.11；95% CI = 1.03 - 1.20）、PTB（OR = 1.16；95% CI = 1.03 - 1.30）和LBW（OR = 1.26；95% CI = 1.10 - 1.44）的风险。本荟萃分析表明，饮用水中的ATR可能是SGA、PTB和LBW的一个风险因素。
