Cacek A T
Ther Drug Monit. 1986;8(2):166-71. doi: 10.1097/00007691-198606000-00007.
Since 1938, phenytoin has been widely used for the control of seizure disorders. Phenytoin is available from a variety of manufacturers in a variety of dosage forms. Certain physiochemical properties of phenytoin may lead to bioavailability changes. The physiochemical properties exert themselves not only in the presence of other drugs but also during the manufacturing process. Manufacturing processes that may influence phenytoin bioavailability include salt form, particle size, product excipient, and dosage form. Drug influences upon phenytoin bioavailability largely include antacid anions, which may form insoluble complexes. Anions present within the diet may also influence the rate and extent of phenytoin absorption. This article reviews the various influences on phenytoin bioavailability with regard to the manufacturing process, antacid, and food.
自1938年以来，苯妥英已被广泛用于控制癫痫发作。苯妥英有多种剂型，由多家制造商生产。苯妥英的某些物理化学性质可能导致生物利用度发生变化。这些物理化学性质不仅在与其他药物合用时会发挥作用，在生产过程中也会如此。可能影响苯妥英生物利用度的生产过程包括盐的形式、粒径、产品辅料和剂型。影响苯妥英生物利用度的药物主要包括抗酸阴离子，它们可能形成不溶性复合物。饮食中存在的阴离子也可能影响苯妥英的吸收速率和程度。本文综述了生产过程、抗酸剂和食物对苯妥英生物利用度的各种影响。
