Luk'ianchuk V D, Zhirnov V V, Trunov V I
Ukr Biokhim Zh (1978). 1986 May-Jun;58(3):83-7.
The morphofunctional state of the rat liver biomembranes is studied under conditions of the peroral effect of alkyl dinitrophenols: dinitroorthocresole and secondary 2,4-dinitro-6-butylphenol. It is established that free radicals and products of peroxide lipid oxidation (diene conjugates, hydroperoxides, final products reacting with 2-thiobarbituric acid) are very important for realization of the membrane-tropic action of the above compounds. Possible mechanisms of development of the membrane-damaging action of these xenobiotics and their effect on the state of the mitochondrial respiratory chain are discussed. The membrane-tropic effect of alkyl dinitrophenols is confirmed by the results of electron-microscopic studies.
在烷基二硝基苯酚（邻二硝基甲酚和仲2,4 - 二硝基 - 6 - 丁基苯酚）经口作用的条件下，对大鼠肝脏生物膜的形态功能状态进行了研究。已确定自由基和过氧化脂质氧化产物（二烯共轭物、氢过氧化物、与2 - 硫代巴比妥酸反应的最终产物）对于实现上述化合物的膜向性作用非常重要。讨论了这些异源生物膜损伤作用发展的可能机制及其对线粒体呼吸链状态的影响。烷基二硝基苯酚的膜向性作用通过电子显微镜研究结果得到证实。
