From the Department of Anesthesiology, Nigde Training and Research Hospital, Nigde, Turkey.
From the Department of Anesthesiology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
Ann Saudi Med. 2023 May-Jun;43(3):166-171. doi: 10.5144/0256-4947.2023.166. Epub 2023 Jun 1.
Intraoperative lactate levels increase in patients undergoing craniotomy, but the reason is not yet fully known. High levels of intraoperative lactate are associated with mortality and morbidity in patients with septic shock and abdominal and cardiac surgery.
Investigate whether intraoperative lactate elevation is associated with postoperative systemic and neurological complications and mortality in craniotomy.
Retrospective study SETTING: University hospital in Turkey.
In this study, we included patients who underwent elective intracranial tumor surgery in our hospital between 1 January 2018, and 31 December 2018. According to the level of intraoperative lactate, patients were divided into two groups: high (≥2.1 mmol/L) and normal (<2.1 mmol/L). The groups were compared by the presence of postoperative new neurological deficits, postoperative surgical and medical complications, mechanical ventilation duration, 30-day mortality, in-hospital mortality, and hospital stay length. Cox regression analysis was performed for the 30-day mortality outcome.
Association between intraoperative lactate levels and postoperative 30-day mortality.
163 patients with lactate data.
While no significant difference was found between the groups regarding age, gender, ASA score, tumor location, operation time and pathology results, preoperative neurologic deficits were higher in the high intraoperative lactate group (=.017). No statically significant difference was found between the groups for postoperative neurological deficit, need for prolonged mechanical ventilation, and hospital stay length. The postoperative 30-day mortality rate was higher in the group with high intraoperative lactate (=.028). High lactate and medical complications were significant in the Cox analysis.
Intraoperative lactate elevation was associated with postoperative 30-day mortality in patients undergoing craniotomy. The intraoperative level of lactate is an important mortality predictor in patients undergoing craniotomy.
Retrospective design and single-centered, missing most data for several variables.
None.
行开颅术的患者术中乳酸水平升高，但原因尚不完全清楚。术中乳酸水平升高与感染性休克、腹部和心脏手术患者的死亡率和发病率相关。
研究开颅术中乳酸升高是否与术后全身和神经系统并发症及死亡率相关。
回顾性研究。
土耳其某大学医院。
本研究纳入了 2018 年 1 月 1 日至 12 月 31 日在我院行择期颅内肿瘤手术的患者。根据术中乳酸水平，患者分为两组：高（≥2.1mmol/L）和正常（＜2.1mmol/L）。通过术后新发神经功能缺损、术后手术和医疗并发症、机械通气时间、30 天死亡率、院内死亡率和住院时间比较两组间差异。采用 Cox 回归分析 30 天死亡率的预后因素。
术中乳酸水平与术后 30 天死亡率的关系。
163 例有乳酸数据的患者。
虽然两组间年龄、性别、ASA 评分、肿瘤位置、手术时间和病理结果无显著差异，但高乳酸组术前神经功能缺损更常见（P=.017）。两组间术后神经功能缺损、需要延长机械通气时间和住院时间无统计学差异。高乳酸组术后 30 天死亡率更高（P=.028）。Cox 分析显示，高乳酸血症和医疗并发症是显著的预后因素。
开颅术患者术中乳酸升高与术后 30 天死亡率相关。术中乳酸水平是开颅术患者重要的死亡率预测指标。
回顾性设计和单中心研究，多个变量缺失大部分数据。
无。
