From the Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
From the King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Ann Saudi Med. 2023 May-Jun;43(3):172-178. doi: 10.5144/0256-4947.2023.172. Epub 2023 Jun 1.
Cancer patients are highly prone to develop bacterial bloodstream infections (BSI) and are also at risk of neutropenia. Knowledge of the prevalence of these infections and whether neutropenia is associated with a change in mortality is important to more effective management and reducing mortality and morbidity.
Estimate the prevalence of bacterial BSI among oncology inpatients and assess the associations of 30-day mortality with Gram stain results and neutropenia.
Retrospective cross-sectional SETTING: University hospital in Saudi Arabia.
We retrieved records of oncology inpatients at King Khalid University Hospital, excluding patients without malignancy and with non-bacterial BSI. The number of records included in the analysis was reduced based on a sample size calculation and systematic random sampling used to select patients to include in the study.
Prevalence of bacterial BSI and association between neutropenia and 30-day mortality.
The prevalence of bacterial bloodstream infections was 18.9% (n=80). Gram-negative bacteria were more prevalent (n=48, 60.0%) than gram-positive bacteria, with the most common being (n=20, 25.0%). The 23 patients (28.8%) who died included 16 (69.6%) with gram-negative infections and 7 (30.4%) with gram-positive infections. There was no statistically significant association of bacterial BSI-related 30-day mortality with Gram stain (=.32). Of 18 patients (22.5%) who were neutropenic, only one (5.6%) died. Sixty-two (77.5%) patients were non-neutropenic, of whom 22 (35.50%) died. We found a statistically significant association between the presence of neutropenia and bacterial BSI-related 30-day mortality (=.016), with mortality being lower among neutropenic patients.
Gram-negative bacteria are more prevalent in bacterial BSI than gram-positive bacteria. No statistically significant association of Gram stain result with mortality was found. However, the 30-day mortality rate was lower among neutropenic patients than among non-neutropenic patients. We recommend further investigation with a larger sample size in multiple regions to further unravel the association of neutropenia with bacterial bloodstream infection-related 30-day mortality.
Lack of regional data and sample size.
None.
癌症患者极易发生细菌性血流感染（BSI），且易并发中性粒细胞减少症。了解这些感染的流行情况以及中性粒细胞减少症是否与死亡率变化相关，对于更有效地管理和降低死亡率和发病率至关重要。
评估肿瘤住院患者中细菌性 BSI 的流行情况，并评估 30 天死亡率与革兰氏染色结果和中性粒细胞减少症之间的关系。
回顾性横断面研究
沙特阿拉伯某大学附属医院。
我们检索了在哈立德国王大学医院就诊的肿瘤住院患者的记录，排除了无恶性肿瘤和非细菌性 BSI 的患者。根据样本量计算和系统随机抽样，减少了纳入分析的记录数量，以选择纳入研究的患者。
细菌性 BSI 的流行情况以及中性粒细胞减少症与 30 天死亡率之间的关系。
423。
细菌性血流感染的流行率为 18.9%（n=80）。革兰氏阴性菌（n=48，60.0%）比革兰氏阳性菌更常见，其中最常见的是（n=20，25.0%）。23 例（28.8%）死亡患者中，16 例（69.6%）为革兰氏阴性菌感染，7 例（30.4%）为革兰氏阳性菌感染。革兰氏染色与细菌性 BSI 相关的 30 天死亡率之间无统计学显著相关性（=0.32）。在 18 例（22.5%）中性粒细胞减少症患者中，只有 1 例（5.6%）死亡。62 例（77.5%）非中性粒细胞减少症患者中，22 例（35.50%）死亡。我们发现中性粒细胞减少症与细菌性 BSI 相关的 30 天死亡率之间存在统计学显著相关性（=0.016），中性粒细胞减少症患者的死亡率较低。
革兰氏阴性菌在细菌性 BSI 中比革兰氏阳性菌更为常见。未发现革兰氏染色结果与死亡率之间有统计学显著相关性。然而，中性粒细胞减少症患者的 30 天死亡率低于非中性粒细胞减少症患者。我们建议进一步扩大样本量在多个地区进行研究，以进一步阐明中性粒细胞减少症与细菌性血流感染相关的 30 天死亡率之间的关系。
缺乏区域性数据和样本量。
无。
