妊娠期糖尿病孕妇中 ATP 结合盒转运蛋白 G1（ABCG1）多态性。
ATP-binding cassette transporter G1 (ABCG1) polymorphisms in pregnant women with gestational diabetes mellitus.
机构信息
Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China; West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, PR China.
Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2023 Aug;287:20-28. doi: 10.1016/j.ejogrb.2023.05.033. Epub 2023 May 30.
CONTEXT AND OBJECTIVES
Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, and it often leads to adverse pregnancy outcomes and seriously harms the health of mothers and infants. ATP-binding cassette transporter G1 (ABCG1) plays critical roles in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. This study was designed to explore the relevance of the ABCG1 polymorphisms in the atherometabolic risk in GDM.
STUDY DESIGN
The case-control population consists of 1504 subjects. The rs2234715 and rs57137919 single nucleotide polymorphisms (SNPs) were genotyped using PCR and DNA sequencing, and clinical and metabolic parameters were determined.
RESULTS
The genotype distributions of the two SNPs showed no difference between the GDM patient and control groups. However, the rs57137919 polymorphism was associated with total cholesterol (TC), and diastolic blood pressure (DBP) levels in patients with GDM. Moreover, subgroup analysis showed that this polymorphism was associated with ApoA1 and DBP levels in overweight/obese patients with GDM, while it was associated with TC, and gestational weight gain (GWG) in non-obese patients with GDM. Meanwhile, the rs2234715 polymorphism was found to be associated with neonatal birth height in non-obese patients with GDM.
CONCLUSIONS
The two polymorphisms in the ABCG1 have an influence on atherometabolic traits, GWG, and fetal growth in GDM, depending on the BMI of the patients.
背景与目的
妊娠期糖尿病（GDM）是妊娠期间最常见的代谢紊乱疾病，常导致不良妊娠结局，严重危害母婴健康。三磷酸腺苷结合盒转运体 G1（ABCG1）在高密度脂蛋白（HDL）代谢和胆固醇逆向转运中发挥关键作用。本研究旨在探讨 ABCG1 多态性与 GDM 患者动脉粥样硬化代谢风险的相关性。
研究设计
病例对照人群由 1504 例受试者组成。采用 PCR 和 DNA 测序检测 rs2234715 和 rs57137919 单核苷酸多态性（SNP），并测定临床和代谢参数。
结果
两个 SNP 的基因型分布在 GDM 患者和对照组之间无差异。然而，rs57137919 多态性与 GDM 患者的总胆固醇（TC）和舒张压（DBP）水平相关。此外，亚组分析显示，该多态性与超重/肥胖 GDM 患者的 ApoA1 和 DBP 水平相关，而与非肥胖 GDM 患者的 TC 和妊娠体重增加（GWG）相关。同时，rs2234715 多态性与非肥胖 GDM 患者的新生儿出生身高相关。
结论
ABCG1 中的两个多态性与 GDM 患者的动脉粥样硬化代谢特征、GWG 和胎儿生长有关，取决于患者的 BMI。
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