Azab Mohammed A
Department of Neurosurgery, Cairo University Faculty of Medicine, Cairo, Egypt.
Cancer Treat Res Commun. 2023;36:100703. doi: 10.1016/j.ctarc.2023.100703. Epub 2023 Apr 6.
Glioblastoma is considered the most aggressive primary brain tumor. Recurrence after treatment is a significant problem with a failed response to optimal treatment. The recurrence of GBM is linked to different cellular and molecular pathways. Nationwide, in Egypt, astrocytic tumors are the most commonly diagnosed CNS tumor. Anaplastic Lymphoma Kinase (ALK CD246) is an enzymatic protein (RTK) belonging to the insulin receptors superfamily.
This is a retrospective study including sixty cases of astrocytic tumors (males = 40, mean age = 31.5), (females = 20, mean age = 37.77) obtained through collecting archived paraffin blocks of astrocytic tumor from the Pathology Department, Cairo University Faculty of Medicine during the period from January 2015 till January 2019. All cases were evaluated for ALK expression trying to find any clinical correlations with the clinical data.
Correlations were made using a scatterplot matrix correlogram. There was a significant correlation between tumor recurrence and ALK expression (r = 0.8, P < 0.01), and incidence of postoperative seizures (r = 0.8, P < 0.05), and between mean age and score tumor (r = 0.8, P < 0.05).
Expression of ALK was found to be abundant among high-grade gliomas and tumor recurrence rate was higher in ALK-positive patients. Further studies are needed to evaluate the potential use of ALK as a prognostic marker in cases of GBM.
胶质母细胞瘤被认为是最具侵袭性的原发性脑肿瘤。治疗后复发是一个严重问题，对最佳治疗无反应。胶质母细胞瘤的复发与不同的细胞和分子途径有关。在埃及全国范围内，星形细胞瘤是最常被诊断出的中枢神经系统肿瘤。间变性淋巴瘤激酶（ALK CD246）是一种属于胰岛素受体超家族的酶蛋白（受体酪氨酸激酶）。
这是一项回顾性研究，纳入了60例星形细胞瘤病例（男性40例，平均年龄31.5岁），（女性20例，平均年龄37.77岁），这些病例是通过收集开罗大学医学院病理科2015年1月至2019年1月期间存档的星形细胞瘤石蜡块获得的。对所有病例进行ALK表达评估，试图找出与临床数据的任何临床相关性。
使用散点图矩阵相关图进行相关性分析。肿瘤复发与ALK表达之间存在显著相关性（r = 0.8，P < 0.01），与术后癫痫发作发生率之间存在显著相关性（r = 0.8，P < 0.05），平均年龄与肿瘤评分之间也存在显著相关性（r = 0.8，P < 0.05）。
发现ALK在高级别胶质瘤中表达丰富，ALK阳性患者的肿瘤复发率更高。需要进一步研究评估ALK作为胶质母细胞瘤病例预后标志物 的潜在用途。
