Ataturk University, Department of Medical Pharmacology, Erzurum 25240, Turkey.
Atatürk University, Faculty of Veterinary, Department of Histology and Embryology, Erzurum 25240, Turkey.
J Vet Sci. 2023 May;24(3):e35. doi: 10.4142/jvs.23023.
Titanium is the most widely used metal for bone integration, especially for cancer patients receiving ionizing radiation. This study aimed to investigate the amifostine administration that would reduce the effects of radiation on bone healing and osseointegration in rat models.
It is aimed that the application of amifostine in rats receiving radiotherapy treatment will reduce the negative effects of ionizing radiation on the bone.
Thirty-five adult male Wistar rats were randomly divided into one healthy and four experimental groups. In three consecutive days, two experimental groups of rats (AMF-RT-IMP and RT-IMP) were exposed to radiation (15 Gy/3 fractions of 5 Gy each). Then the titanium implants were inserted into the left tibia. Before the radiotherapy process, a 200 mg/kg dose of amifostine (AMF) was administered to the rats in the AMF-IMP and AMF-RT-IMP groups. Twenty-eight days after the screw implant, all rats were sacrificed, and their blood samples and tibia bones were collected for analysis.
The results indicated an accelerated bone formation and a more rapid healing process in the screw implants in the AMF-IMP, AMF-RT-IMP, and AMF-RT groups than in the RT-IMP group. Also, bone-implant contact area measurement and inflammation decreased with amifostine treatment in the implants subjected to irradiation ( < 0.05).
The results obtained in the present study suggested that amifostine prevents the losses of bone minerals, bone integrity, and implant position from ionizing-radiation when given before exposure.
钛是最常用于骨整合的金属，尤其适用于接受电离辐射的癌症患者。本研究旨在探讨氨磷汀给药可减少电离辐射对大鼠模型骨愈合和骨整合的影响。
旨在研究氨磷汀在接受放射治疗的大鼠中的应用将减少电离辐射对骨骼的负面影响。
35 只成年雄性 Wistar 大鼠随机分为健康组和 4 个实验组。连续 3 天，两组实验组大鼠（AMF-RT-IMP 和 RT-IMP）接受辐射（15Gy/3 次，每次 5Gy）。然后将钛植入物插入左胫骨。在放射治疗前，AMF-IMP 和 AMF-RT-IMP 组的大鼠给予 200mg/kg 剂量的氨磷汀（AMF）。在螺钉植入后 28 天，所有大鼠被处死，收集其血液样本和胫骨进行分析。
结果表明，与 RT-IMP 组相比，AMF-IMP、AMF-RT-IMP 和 AMF-RT 组的螺钉植入物中骨形成加速，愈合过程更快。此外，在接受照射的植入物中，氨磷汀治疗可减少骨-植入物接触面积测量值和炎症（<0.05）。
本研究结果表明，氨磷汀可预防电离辐射暴露前给药对骨矿物质、骨完整性和植入物位置的丢失。
