a:1:{s:5:"en_US";s:19:"University of Parma";}.
University of Parma.
Acta Biomed. 2023 Jun 5;94(S1):e2023111. doi: 10.23750/abm.v94iS1.13879.
Wernicke's encephalopathy is an under-recognized life-threatening disease caused by thiamine (vitamin B1) deficiency. It has historically been related to chronic alcoholic intake but other causes of malnutrition, such as invasive gastric surgery and hyperemesis, have been linked to the onset of this illness over the years, often presenting with atypical clinical manifestations. Herein we report a case of a young obese woman affected by non-alcoholic Wernicke's Encephalopathy following a minimally invasive gastrointestinal surgery. She showed an unusual clinical profile characterized by prominent subacute neuro-ophthalmological involvement which combined to her juvenile age, overweight condition and brain lesions, have made diagnosis challenging due to similarities with Neuromyelitis Optica Spectrum Disorder. Our case underscores the relevance of prompt diagnosis in order to prevent the development of irreversible neuropathological changes and to avoid the use of a long-term immunosuppressive treatment.
威尼克脑病是一种由硫胺素（维生素 B1）缺乏引起的未被充分认识的危及生命的疾病。它历史上与慢性酒精摄入有关，但其他营养不良的原因，如侵袭性胃手术和妊娠剧吐，近年来也与这种疾病的发生有关，其临床表现常不典型。在此，我们报告了一例年轻肥胖女性在接受微创胃肠手术后发生非酒精性威尼克脑病的病例。她表现出一种不寻常的临床特征，突出表现为亚急性神经眼病变，结合其年轻的年龄、超重状况和脑部病变，由于与视神经脊髓炎谱系障碍相似，使得诊断具有挑战性。我们的病例强调了及时诊断的重要性，以防止不可逆的神经病理变化的发展，并避免长期使用免疫抑制治疗。
