Shlosberg A, Perl S, Yakobson B, Klopfer U, Egyed M N, Nobel T A, Efron Y
Vet Hum Toxicol. 1986 Jun;28(3):230-3.
Feedlot calves given monensin in their feed developed an excessive mortality which peaked 3-4 mo after monensin was withdrawn. Typically the calves died suddenly and necropsy revealed areas of paleness in the skeletal muscles (early cases) and in the myocardium (more chronic cases). Histology (in 19 calves) showed swollen myocytes with loss of striation and sarcoplasmic vacuolization, followed by the appearance of necrotic fibres and infiltration with macrophages and neutrophils, and finally local and generalized fibrosis. Calcification was not evident. A differential diagnosis ruled out an etiology of nutritional and toxicological origin, thus leaving the probability of atypical (chronic) monensin toxicosis.
在饲养场中，饲料中添加莫能菌素的犊牛死亡率过高，在停用莫能菌素3 - 4个月后达到峰值。通常情况下，犊牛会突然死亡，尸检发现骨骼肌（早期病例）和心肌（更慢性的病例）出现苍白区域。组织学检查（对19头犊牛）显示，肌细胞肿胀，横纹消失，肌浆空泡化，随后出现坏死纤维，并有巨噬细胞和中性粒细胞浸润，最终出现局部和全身性纤维化。未发现钙化现象。鉴别诊断排除了营养和毒理学方面的病因，因此怀疑是非典型（慢性）莫能菌素中毒。
