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用于可控局部给药的载氢化可的松脂质-聚合物杂化纳米粒：制剂设计优化及体外和体内评价

Hydrocortisone-Loaded Lipid-Polymer Hybrid Nanoparticles for Controlled Topical Delivery: Formulation Design Optimization and In Vitro and In Vivo Appraisal.

作者信息

Alsaidan Omar Awad, Elmowafy Mohammed, Shalaby Khaled, Alzarea Sami I, Massoud Diaa, Kassem Abdulsalam M, Ibrahim Mohamed F

机构信息

Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.

Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.

出版信息

ACS Omega. 2023 May 19;8(21):18714-18725. doi: 10.1021/acsomega.3c00638. eCollection 2023 May 30.

DOI:10.1021/acsomega.3c00638
PMID:37273643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10233847/
Abstract

The barrier functionalities of the skin offer a major but not insuperable hindrance for fabrication of skin delivery effective systems. This work aimed to develop an optimized lipid polymer hybrid nanoparticle and assess the skin delivery effectiveness of hydrocortisone (9.872 ± 0.361 × 10 cm/h) of a drug through the skin from an optimized formulation when compared with a drug solution. Meanwhile, histological examination after topical application of the optimized formulation showed a safe increase in epidermal thickness. In vivo, the optimized formulation showed promising anti-inflammatory activity in a croton oil-induced ear rosacea model. As an excellent anti-inflammatory agent, these findings propose that the use of lipomers could be a promising strategy to improve the topical effectiveness of hydrocortisone acetate (HCA) against inflammatory diseases. Collectively, these results support our view that lipid polymer hybrid nanoparticles can proficiently deliver hydrocortisone to the skin in treating skin inflammatory conditions.

摘要

皮肤的屏障功能对制备有效的皮肤给药系统构成了重大但并非不可克服的障碍。这项工作旨在开发一种优化的脂质聚合物杂化纳米颗粒，并评估氢化可的松（9.872 ± 0.361 × 10 cm/h）通过优化配方经皮给药的有效性，并与药物溶液进行比较。同时，局部应用优化配方后的组织学检查显示表皮厚度安全增加。在体内，优化配方在巴豆油诱导的耳部酒渣鼻模型中显示出有前景的抗炎活性。作为一种优秀的抗炎剂，这些发现表明使用脂质体可能是提高醋酸氢化可的松（HCA）对炎症性疾病局部疗效的一种有前景的策略。总体而言，这些结果支持了我们的观点，即脂质聚合物杂化纳米颗粒可以有效地将氢化可的松递送至皮肤以治疗皮肤炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/2852a6413524/ao3c00638_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/22b9f2f6bef3/ao3c00638_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/bace318a4589/ao3c00638_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/b3ce5944c304/ao3c00638_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/f643ab88da9d/ao3c00638_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/5a5441faed9b/ao3c00638_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/b80c78fd2f0b/ao3c00638_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/f200771e5bf0/ao3c00638_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/b9f8af306cad/ao3c00638_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/2852a6413524/ao3c00638_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/22b9f2f6bef3/ao3c00638_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/bace318a4589/ao3c00638_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/b3ce5944c304/ao3c00638_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/f643ab88da9d/ao3c00638_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/5a5441faed9b/ao3c00638_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/b80c78fd2f0b/ao3c00638_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/f200771e5bf0/ao3c00638_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/b9f8af306cad/ao3c00638_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/10233847/2852a6413524/ao3c00638_0010.jpg

相似文献

[1]
Hydrocortisone-Loaded Lipid-Polymer Hybrid Nanoparticles for Controlled Topical Delivery: Formulation Design Optimization and In Vitro and In Vivo Appraisal.

ACS Omega. 2023-5-19

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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J Ethnopharmacol. 2018-9-6

[8]
Nasturtium officinale R. Br. effectively reduces the skin inflammation induced by croton oil via glucocorticoid receptor-dependent and NF-κB pathways without causing toxicological effects in mice.

J Ethnopharmacol. 2018-10-17

[9]
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[10]
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[2]
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[3]
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[4]
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[5]
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本文引用的文献

[1]
A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris.

Polymers (Basel). 2022-6-28

[2]
Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: and evaluation.

Drug Deliv. 2022-12

[3]
Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation.

Colloids Surf B Biointerfaces. 2021-7

[4]
Spironolactone-Loaded LeciPlexes as Potential Topical Delivery Systems for Female Acne: In Vitro Appraisal and Ex Vivo Skin Permeability Studies.

Pharmaceutics. 2019-12-25

[5]
Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies.

Int J Pharm. 2019-11-9

[6]
Topical corticosteroids in clinical practice.

Med J Malaysia. 2019-4

[7]
Lipomers (Lipid-polymer Hybrid Particles) of Vardenafil Hydrochloride: a Promising Dual Platform for Modifying the Drug Release Rate and Enhancing Its Oral Bioavailability.

AAPS PharmSciTech. 2018-10-5

[8]
Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation.

Eur J Pharm Sci. 2018-7-4

[9]
Chitosan based polymer-lipid hybrid nanoparticles for oral delivery of enoxaparin.

Int J Pharm. 2018-6-1

[10]
Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects.

Drug Deliv Transl Res. 2019-4

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