Turesky Ted K, Luetje Megan M, Eden Guinevere F
Center for the Study of Learning, Georgetown University Medical Center, Washington, DC, United States.
Front Neurosci. 2023 May 18;17:1135437. doi: 10.3389/fnins.2023.1135437. eCollection 2023.
Developmental dyslexia is a language-based reading disability, yet some have reported motor impairments, usually attributed to cerebellar dysfunction.
Using fMRI, we compared children with and without dyslexia during irregularly paced, left or right-hand finger tapping. Next, we examined seed-to-voxel intrinsic functional connectivity (iFC) using six seed regions of the motor system (left and right anterior lobe of the cerebellum, SM1 and SMA).
A whole-brain task-evoked analysis revealed relatively less activation in the group with dyslexia in right anterior cerebellum during right hand tapping. For iFC, we found the group with dyslexia to have greater iFC between the right SM1 seed and a medial aspect of right postcentral gyrus for left hand tapping; and greater iFC between the left SM1 seed and left thalamus, as well as weaker local iFC around the left SM1 seed region for right hand tapping. Lastly, extracted activity and connectivity values that had been identified in these between-group comparisons were not correlated with measures of reading.
We conclude that there are some aberrations in motor system function in children with dyslexia, but these are not tied to reading ability.
发育性阅读障碍是一种基于语言的阅读障碍，但一些人报告称存在运动障碍，通常归因于小脑功能障碍。
我们使用功能磁共振成像（fMRI），在不规则节奏的左手或右手手指敲击过程中，对患有和未患有阅读障碍的儿童进行了比较。接下来，我们使用运动系统的六个种子区域（小脑左右前叶、初级运动皮层（SM1）和辅助运动区（SMA））检查了种子到体素的内在功能连接（iFC）。
全脑任务诱发分析显示，在右手敲击过程中，阅读障碍组右侧小脑前叶的激活相对较少。对于iFC，我们发现阅读障碍组在左手敲击时，右侧SM1种子与右侧中央后回内侧之间的iFC更大；在右手敲击时，左侧SM1种子与左侧丘脑之间的iFC更大，并且左侧SM1种子区域周围的局部iFC较弱。最后，在这些组间比较中确定的提取活动和连接值与阅读测量指标无关。
我们得出结论，阅读障碍儿童的运动系统功能存在一些异常，但这些异常与阅读能力无关。
