Almatov K T, Mirtalipov D T, Kasymova G M, Abidov A
Vopr Med Khim. 1986 May-Jun;32(3):27-30.
Phospholipid composition and oxidative phosphorylation were studied in liver mitochondria of rats with experimental chronic hepatitis. The hepatitis was simulated by means of two hepatotropic drugs--heliotrin and CCl4. Content of phosphatidyl inositol was decreased and that of phosphatidic acid--increased in the hepatitis independently of the nature of the agent inducing the disease. At the same time, content of lysophosphatidyl ethanolamine was decreased but content of lysocardiolipine and lysophosphatidic acid was increased. In CCl4-induced hepatitis content of cardiolipine and sphingomyelin was decreased, whereas after the treatment with heliotrin content of cardiolipine in liver tissue was unaltered and that of sphingomyelin was increased. Content of lysophosphatidyl choline was considerably increased in CCl4-hepatitis but it was only slightly altered after the treatment with heliotrin. The most pronounced alterations in the phospholipid spectrum and oxidative phosphorylation were found in liver mitochondria in the CCl4-induced hepatitis.
对患有实验性慢性肝炎大鼠的肝脏线粒体中的磷脂组成和氧化磷酸化进行了研究。通过两种亲肝药物——天芥菜精和四氯化碳模拟肝炎。在肝炎中，无论引发疾病的药物性质如何，磷脂酰肌醇含量降低，而磷脂酸含量增加。同时，溶血磷脂酰乙醇胺含量降低，但溶血心磷脂和溶血磷脂酸含量增加。在四氯化碳诱导的肝炎中，心磷脂和鞘磷脂含量降低，而在用天芥菜精治疗后，肝组织中心磷脂含量未改变，鞘磷脂含量增加。在四氯化碳诱导的肝炎中，溶血磷脂酰胆碱含量显著增加，但在用天芥菜精治疗后仅略有改变。在四氯化碳诱导的肝炎中，肝脏线粒体中的磷脂谱和氧化磷酸化变化最为明显。
