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[磷脂酰胆碱脂质体在实验性中毒性肝炎中的保护作用]

[Protective effect of phosphatidylcholine liposomes in experimental toxic hepatitis].

作者信息

Boldanova N B, Migushina V L, Shatinina S Z, Dobrynina O V

出版信息

Vopr Med Khim. 1986 May-Jun;32(3):65-8.

PMID:3727472
Abstract

Level of fructose-1-monophosphate aldolase was decreased in blood serum after administration of phosphatidyl choline-containing liposomes into male rats with experimental toxic hepatitis caused by treatment with hepatotropic poison CCl4 at a dose of 0.25 ml/100 g of body mass. The rate of the aldolase level normalization depends on composition of liposomes as well as on the pathway of their administration.

摘要

在用剂量为0.25毫升/100克体重的亲肝毒物四氯化碳处理导致实验性中毒性肝炎的雄性大鼠后,给予含磷脂酰胆碱的脂质体,血清中果糖-1-磷酸醛缩酶水平降低。醛缩酶水平恢复正常的速率取决于脂质体的组成及其给药途径。

相似文献

1
[Protective effect of phosphatidylcholine liposomes in experimental toxic hepatitis].[磷脂酰胆碱脂质体在实验性中毒性肝炎中的保护作用]
Vopr Med Khim. 1986 May-Jun;32(3):65-8.
2
[Phosphatidylcholine-induced repair of damaged hepatocyte membranes in heliotrine poisoning].[磷脂酰胆碱诱导的天芥菜碱中毒中受损肝细胞膜修复]
Biull Eksp Biol Med. 1987 Apr;103(4):413-5.
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[Serum aldolase isozymes in rats with acute liver injury].
Igaku To Seibutsugaku. 1969 Feb 2;78(2):69-72.
4
[On the correlation fo fructosediphosphate and fructosemonophosphate aldolase activities in rat tissues under toxic conditions and starvation].
Vopr Med Khim. 1966 Sep-Oct;12(5):522-6.
5
[Fructose phosphate aldolase in experimental liver damage in rats. 3. Liver damage with carbon tetrachloride].[大鼠实验性肝损伤中的磷酸果糖醛缩酶。3. 四氯化碳所致肝损伤]
Z Klin Chem Klin Biochem. 1970 Jan;8(1):35-7.
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[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Biull Eksp Biol Med. 1973 May;75(5):24-7.
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Effect of x-irradiation and fasting on hepatotoxicity of carbon tetrachloride in rats.X射线照射和禁食对大鼠四氯化碳肝毒性的影响。
Radiat Res. 1973 Jun;54(3):444-52.
8
[Rat plasma enzyme activity in various types of acute toxic liver lesions].
Biull Eksp Biol Med. 1968 May;65(5):60-3.
9
[Use of phospholipids to repair rat liver membranes during carbon tetrachloride poisoning].[利用磷脂修复四氯化碳中毒大鼠肝细胞膜]
Biull Eksp Biol Med. 1987 Sep;104(9):301-3.
10
Changes of aldolase isozyme gene expression in CCl4 induced liver damage.四氯化碳诱导的肝损伤中醛缩酶同工酶基因表达的变化。
Gastroenterol Jpn. 1990 Aug;25(4):511. doi: 10.1007/BF02779346.