Famelis Nikolaos, Geibel Sebastian, van Tol Daan
Institute for Molecular Infection Biology, Julius Maximilian University of Würzburg, D-97080 Würzburg, Germany.
Leiden Institute of Chemistry, Leiden University, NL-2333 CC Leiden, Netherlands.
Biol Chem. 2023 Jun 7;404(7):691-702. doi: 10.1515/hsz-2022-0350. Print 2023 Jun 27.
Mycobacteria, such as the pathogen , utilize up to five paralogous type VII secretion systems to transport proteins across their cell envelope. Since these proteins associate in pairs that depend on each other for transport to a different extent, the secretion pathway to the bacterial surface remained challenging to address. Structural characterization of the inner-membrane embedded secretion machineries along with recent advances on the substrates' co-dependencies for transport allow for the first time more detailed and testable models for secretion.
分枝杆菌，如病原体，利用多达五种同源的VII型分泌系统将蛋白质运输穿过其细胞包膜。由于这些蛋白质成对结合，在运输过程中相互依赖的程度不同，因此通向细菌表面的分泌途径仍然难以解决。对内膜嵌入的分泌机制的结构表征以及底物运输的共依赖性方面的最新进展，首次为分泌提供了更详细且可检验的模型。
