Mest H J, Thomas E
Z Gesamte Inn Med. 1986 Apr 15;41(8):217-20.
In a survey experimental and clinical investigations on Trapidil (Rocornal) are briefly demonstrated. The great number of recent investigations, particularly by Japanese authors, render it necessary anew to think over the application of Trapidil in the GDR. Apart from possibilities of the treatment of the ischaemic heart disease, the survey shows further possible indications, such as inhibitions or the aggregation of thrombocytes, improvement of the microcirculation and treatment of hyperlipidaemias. It was made evident that Trapidil induces no steal phenomenon and thus a restriction as an antianginal pharmacon it not justified. A renaissance for Trapidil indicates itself.
本文简要介绍了有关曲匹地尔(Rocornal)的调查、实验及临床研究情况。近期大量的研究,尤其是日本学者的研究,使得人们有必要重新思考曲匹地尔在民主德国的应用。除了治疗缺血性心脏病的可能性外,该调查还显示了其他可能的适应症,如抑制血小板聚集、改善微循环以及治疗高脂血症。已证实曲匹地尔不会引发窃血现象,因此将其作为抗心绞痛药物加以限制是不合理的。曲匹地尔有望再度兴起。