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依替巴肽鼻喷剂:治疗阵发性室上性心动过速的治疗潜力。

Etripamil Nasal Spray: Therapeutic Potential for Treating Paroxysmal Supraventricular Tachycardia.

机构信息

College of Pharmacy, University of Florida, Jacksonville, FL, USA.

East Coast Institute for Research, Jacksonville, FL, USA.

出版信息

Am J Cardiovasc Drugs. 2023 Sep;23(5):471-475. doi: 10.1007/s40256-023-00589-2. Epub 2023 Jun 6.

Abstract

Patients with arrythmias are at an increased risk of heart-related comorbidities and complications. Specifically, patients with paroxysmal supraventricular tachycardia (PSVT), a type of arrythmia, are at increased risk of lightheadedness or shortness of breath, due to the increased rate of the heartbeat. Most patients are prescribed oral medications to control their heart rates and maintain a normal heart rhythm. Researchers have been tasked with discovering alternative treatment options with new delivery methods to treat arrythmias such as PSVT. A nasal spray was subsequently designed and is currently undergoing clinical studies. This review aims to present and discuss the current clinical and scientific evidence pertaining to etripamil.

摘要

心律失常患者发生心脏相关合并症和并发症的风险增加。具体而言,阵发性室上性心动过速(PSVT)是一种心律失常,由于心跳加快,患者出现头晕或呼吸急促的风险增加。大多数患者被开具口服药物来控制心率并维持正常的心律。研究人员的任务是发现新的给药方法的替代治疗选择,以治疗 PSVT 等心律失常。随后设计了一种鼻腔喷雾剂,目前正在进行临床研究。本综述旨在介绍和讨论与艾司他哌仑相关的当前临床和科学证据。

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