Martin G R, Brown K S, Matheson D W, Lebowitz H, Singer L, Ophaug R
Mutat Res. 1979 Feb;66(2):159-67. doi: 10.1016/0165-1218(79)90061-2.
We have examined the possible effect of fluoride intake on chromosome damage. There was no evidence of increased frequency of chromosomal aberration in bone marrow or testis cells of mice with either 50 ppm fluoride intake over several generations or 100 ppm intake for 6 weeks compared to animals drinking distilled water. Fluoride was not found to be mutagenic in a widely used bacterial mutagenesis assay over a range of 0.1 to as high as 2000 microgram fluoride per plate.
我们研究了氟摄入对染色体损伤的可能影响。与饮用蒸馏水的动物相比，连续几代摄入50 ppm氟的小鼠或摄入100 ppm氟6周的小鼠，其骨髓或睾丸细胞中染色体畸变频率均无增加的迹象。在广泛使用的细菌诱变试验中，每平板0.1至高达2000微克氟的范围内，未发现氟具有致突变性。
