The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Asia Pac Psychiatry. 2023 Jun;15(2-3):e12538. doi: 10.1111/appy.12538. Epub 2023 Jun 6.
Major depressive disorder (MDD) has been found to be nearly twice as prevalent in females as in males. One hypothesis proposed that abused females were particularly prone to MDD. We aim to examine the sex-specific associations between various types of childhood trauma and MDD.
In this study, 290 outpatients diagnosed with MDD were recruited from Beijing Anding Hospital, and 290 healthy volunteers were recruited from neighborhoods nearby the hospital, with sex, age, and family history matched. Childhood Trauma Questionnaire-Short Form (CTQ-SF) developed by Bernstein et al. was used to assess the severity of five different types of childhood abuse and neglect. McNemar's test and conditional logistic regression models with potential confounders (i.e., marital status, educational level, and body mass index) controlled were used to explore the sex-specific associations between different types of childhood maltreatment and MDD.
In the full sample, patients with MDD showed a significant higher rate of any childhood maltreatment (i.e., emotional abuse, sexual abuse, physical abuse, emotional neglect, and physical neglect). Among females, all types of childhood abuse were statistically significant. For males, significant differences were only found in emotional abuse and in emotional neglect.
It would appear that MDD in the outpatients is associated with any type of childhood trauma in women and emotional abuse or neglect in men.
重度抑郁症（MDD）在女性中的患病率几乎是男性的两倍。有一种假设认为，受虐待的女性尤其容易患 MDD。我们旨在研究各种类型的儿童创伤与 MDD 之间的性别特异性关联。
本研究招募了 290 名在北京安定医院诊断为 MDD 的门诊患者和 290 名来自医院附近社区的健康志愿者，性别、年龄和家族史相匹配。采用 Bernstein 等人开发的童年创伤问卷-短表（CTQ-SF）评估五种不同类型的儿童虐待和忽视的严重程度。采用 Mcnemar 检验和条件逻辑回归模型（控制潜在混杂因素，如婚姻状况、教育水平和体重指数），探讨不同类型的儿童虐待与 MDD 之间的性别特异性关联。
在全样本中，患有 MDD 的患者有更高的任何童年虐待（即情感虐待、性虐待、身体虐待、情感忽视和身体忽视）发生率。在女性中，所有类型的儿童虐待均具有统计学意义。对于男性，仅在情感虐待和情感忽视中发现显著差异。
似乎门诊患者的 MDD 与女性的任何类型的儿童创伤以及男性的情感虐待或忽视有关。
