基于糠醛型亚胺配体和 2,2'-联吡啶的单核混合配体配合物的合成、结构表征及抗菌评价
Synthesis, structural characterization, and antimicrobial evaluation of new mononuclear mixed ligand complexes based on furfural-type imine ligand, and 2,2'-bipyridine.
机构信息
Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.
Chemistry Department, Faculty of Science (Girl's), Al-Azhar University, Youssif Abbas St., P.O. Box 11754, Nasr City, Cairo, Egypt.
出版信息
Sci Rep. 2023 Jun 6;13(1):9196. doi: 10.1038/s41598-023-36060-0.
The present investigation goal was to investigate the chemistry of four new mononuclear mixed ligand Fe(III), Co(II), Cu(II), and Cd(II) complexes constructed from furfural-type imine ligand (L), and the co ligand 2,2'-bipyridine in addition to assessing their antimicrobial activity against some bacterial, and fungi strains. The structure of the complexes was interpreted by different spectroscopic techniques such as MS, IR, H NMR, UV-Vis, elemental analysis, TG-DTG, conductivity, and magnetic susceptibility measurements. The correlation of all results revealed that ligand (L) acts as a neutral ONNO tetradentate whereas the co ligand acts as a neutral NN bidentate. The coordination of the ligands with the metal ions in a molar ratio of 1:1:1 leads to formation of an octahedral geometry around the metal ions. The octahedral geometry has been validated and optimized by DFT analysis. Conductivity data showed the electrolytic nature of all complexes. The thermal stability of all complexes was deduced in addition to evaluating some thermodynamic, and kinetic parameters using Coats-Redfern method. Furthermore, all complexes in comparison to their parent ligands were tested for their biological potency against some pathogenic bacterial, and fungi strains using the paper disk diffusion method. CdL(bpy) complex revealed the highest antimicrobial activity.
本研究旨在探讨四种新型单核混合配体 Fe(III)、Co(II)、Cu(II) 和 Cd(II)配合物的化学性质，这些配合物是由糠醛型亚胺配体 (L) 和辅助配体 2,2'-联吡啶构建而成，并评估它们对一些细菌和真菌菌株的抗菌活性。通过不同的光谱技术，如 MS、IR、H NMR、UV-Vis、元素分析、TG-DTG、电导率和磁化率测量，对配合物的结构进行了解释。所有结果的相关性表明，配体 (L) 作为中性的 ONNO 四齿配体，而辅助配体作为中性的 NN 二齿配体。配体与金属离子以 1:1:1 的摩尔比配位，导致金属离子周围形成八面体几何形状。通过 DFT 分析验证和优化了八面体几何形状。电导率数据表明所有配合物均具有电解性质。通过 Coats-Redfern 方法，推断了所有配合物的热稳定性，并评估了一些热力学和动力学参数。此外，通过纸片扩散法，将所有配合物与它们的母体配体进行了对一些致病细菌和真菌菌株的生物效力测试。CdL(bpy)配合物显示出最高的抗菌活性。
Zotero 插件