Delbro D, Lisander B, Andersson S A
Acta Physiol Scand. 1986 May;127(1):111-7. doi: 10.1111/j.1748-1716.1986.tb07882.x.
Gastric motor responses, recorded as volume changes of an intragastric balloon, were induced by the close i.a. administration of bradykinin (0.75-4 micrograms) in chloralose-anaesthetized cats. The animals were vagotomized and the adrenals were ligated at the outset of the experiments. Prior to autonomic blocking agents bradykinin elicited relaxatory or biphasic motor responses. Following nicotinic ganglionic receptor blockade bradykinin caused predominantly gastric contractions. Such excitatory responses were antagonized by 80-100% by atropine, suggesting a dominant neurogenic component. An hypothesis is put forward that the observed gastric contractions result from a bradykinin-induced activation of an axon reflex arrangement confined to thin sensory nerve fibres which, by substance P release from intramural collaterals, excite postganglionic cholinergic motor neurones.
在水合氯醛麻醉的猫中，通过腹腔内近距离注射缓激肽（0.75 - 4微克）诱发胃运动反应，以胃内气囊的容积变化记录。实验开始时，动物进行了迷走神经切断术并结扎了肾上腺。在使用自主神经阻滞剂之前，缓激肽引起舒张性或双相运动反应。在烟碱型神经节受体阻断后，缓激肽主要引起胃收缩。这种兴奋反应被阿托品80 - 100%拮抗，提示主要是神经源性成分。提出了一个假说，即观察到的胃收缩是由缓激肽诱导激活局限于细感觉神经纤维的轴突反射机制所致，该机制通过壁内侧支释放P物质来兴奋节后胆碱能运动神经元。
