Soares Michael J, Chapman Belinda M, Kamei Takayuki, Yamamoto Toshiya
Department of Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Dev Growth Differ. 1995 Aug;37(4):355-364. doi: 10.1046/j.1440-169X.1995.t01-3-00001.x.
Trophoblast cell differentiation is crucial to the morphogenesis of the placenta and thus the establishment of pregnancy and the growth and development of the embryo/fetus. In the present review, we discuss current evidence for the existence of regulatory genes crucial to trophoblast cell differentiation and placental morphogenesis. The elucidation of regulatory pathways controlling normal differentiation of trophoblast cells will facilitate the identification of sensitive junctures in the regulatory pathways leading to various developmental disorders, including those associated with the initiation of pregnancy, fetal growth retardation and gestational trophoblast disease.
滋养层细胞分化对于胎盘的形态发生至关重要，因此对妊娠的建立以及胚胎/胎儿的生长发育也至关重要。在本综述中，我们讨论了目前关于存在对滋养层细胞分化和胎盘形态发生至关重要的调控基因的证据。阐明控制滋养层细胞正常分化的调控途径将有助于识别导致各种发育障碍的调控途径中的敏感节点，包括那些与妊娠起始、胎儿生长受限和妊娠滋养层疾病相关的发育障碍。
