低钾血症对正常及缺血犬心脏心室颤动易感性的影响。

Effect of hypokalemia on susceptibility to ventricular fibrillation in the normal and ischemic canine heart.

作者信息

Hohnloser S H, Verrier R L, Lown B, Raeder E A

出版信息

Am Heart J. 1986 Jul;112(1):32-5. doi: 10.1016/0002-8703(86)90674-5.

Abstract

To examine the impact of hypokalemia on cardiac electrical stability, the thresholds for repetitive extrasystole and ventricular fibrillation were determined before and after potassium depletion in 15 chloralose-anesthetized dogs. A reduction in serum potassium concentration from 3.6 to 2.1 mEq/L induced by hemodialysis decreased the repetitive extrasystole threshold by 30% and the ventricular fibrillation threshold by 25% (p less than 0.01). The increase in ventricular vulnerability following acute coronary occlusion was markedly augmented by concomitant potassium depletion. Thus, hypokalemia enhances the propensity for ventricular fibrillation in the normal as well as in the ischemic canine heart. These findings shed light on clinical observations of enhanced susceptibility to life-threatening arrhythmias during acute myocardial ischemia in hypokalemic patients.

摘要

为研究低钾血症对心脏电稳定性的影响，测定了15只水合氯醛麻醉犬在钾耗竭前后的重复性期外收缩阈值和室颤阈值。血液透析导致血清钾浓度从3.6毫当量/升降至2.1毫当量/升，使重复性期外收缩阈值降低30%，室颤阈值降低25%（p<0.01）。急性冠状动脉闭塞后心室易损性的增加因伴随的钾耗竭而显著增强。因此，低钾血症增加了正常犬和缺血犬心脏发生室颤的倾向。这些发现为低钾血症患者急性心肌缺血期间对危及生命心律失常易感性增加的临床观察提供了依据。