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[免疫调节与多糖结构之间的关系]

[Relationship between immune regulation and structure of polysaccharides].

作者信息

Chen Nuo, Xi Wen-Jie, Hu Mei-Fen, Wei Xing-Ye, Xiao Ping, Duan Jin-Ao

机构信息

Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization , Nanjing University of Chinese Medicine Nanjing 210023, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2023 May;48(10):2667-2678. doi: 10.19540/j.cnki.cjcmm.20221220.601.

Abstract

Polysaccharides have significant immunomodulatory activity and have good development value in food and medicine fields. At present, there are many studies on the chemical structure and immune activity of polysaccharides, but the relationship between them of polysaccharides has not been fully explained, which limits the further development and utilization of polysaccharide resources. The immune activity of polysaccharides is closely related to their own structure. This paper systematically summarized the relationship between the relative molecular weight, monosaccharide composition, glycosidic bond types, chemical modification, and advanced conformation of polysaccharides and the immune regulation, aiming to provide references for the profound study of polysaccharide structure-activity relationship and utilization of polysaccharides.

摘要

多糖具有显著的免疫调节活性,在食品和医药领域具有良好的开发价值。目前,关于多糖的化学结构和免疫活性已有诸多研究,但多糖二者之间的关系尚未完全阐明,这限制了多糖资源的进一步开发与利用。多糖的免疫活性与其自身结构密切相关。本文系统综述了多糖的相对分子质量、单糖组成、糖苷键类型、化学修饰及高级构象与免疫调节之间的关系,旨在为深入研究多糖构效关系及多糖的利用提供参考。

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