Fu Ting-Ting, Yin Xing-Bin, Cai Meng-Ru, Zhu Rong-Yue, Huang Hua-Ting, Liao Shi-Lang, Qu Chang-Hai, Dong Xiao-Xu, Zhou Yue-Hua, Ni Jian
School of Chinese Material Medica, Beijing University of Chinese Medicine Beijing 100029,China.
Center for Drug Evaluation, National Medical Products Administration Beijing 100022, China.
Zhongguo Zhong Yao Za Zhi. 2023 May;48(10):2699-2712. doi: 10.19540/j.cnki.cjcmm.20230308.302.
Fermented Chinese medicine has long been used. Amid the advance for preservation of experience, the connotation of fermented Chinese medicine has been enriched and improved. However, fermented Chinese medicine prescriptions generally contain a lot of medicinals. The fermentation process is complicated and the conventional fermentation conditions fail to be strictly controlled. In addition, the judgment of the fermentation end point is highly subjective. As a result, quality of fermented Chinese medicine is of great difference among regions and unstable. At the moment, the quality standards of fermented Chinese medicine are generally outdated and different among regions, with simple quality control methods and lacking objective safe fermentation-specific evaluation indictors. It is difficult to comprehensively evaluate and control the quality of fermented medicine. These problems have aroused concern in the industry and also affected the clinical application of fermented Chinese medicine. This article summarized and analyzed the application, quality standards, and the modernization of fermentation technology and quality control methods of fermented Chinese medicine and proposed suggestions for improving the quality standards of the medicine, with a view to improving the overall quality of it.
