Zhang Mutang, Jiang Hao, Ou Shaobi, Qian Min, Qi Heming, Chen Junping, Zeng Xiaofang, Bai Weidong, Xiao Gengsheng
College of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food, Ministry of Agriculture, Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Crit Rev Food Sci Nutr. 2024;64(27):9992-10008. doi: 10.1080/10408398.2023.2219758. Epub 2023 Jun 7.
Sinensetin is among the most ubiquitous polyphenols in citrus fruit and recently has been extensively studied for its ability to prevent or treat diseases. The current literature on the bioavailability of sinensetin and its derivatives was reviewed and the potential ameliorative effects of metabolic syndrome in humans were evaluated. Sinensetin and its derivatives mainly aggregated in the large intestine and extensively metabolized through gut microbiota (GM) and the liver. So intestinal microorganisms had a significant influence on the absorption and metabolism of sinensetin. Interestingly, not only GM acted on sinensetin to metabolize them, but sinensetin also regulated the composition of GM. Thus, sinensetin was metabolized as methyl, glucuronide and sulfate metabolites in the blood and urine. Furthermore, sinensetin was reported to have the beneficial effect of ameliorating metabolic syndromes, including disorders of lipid metabolism (obesity, NAFLD, atherosclerosis), glucose metabolism disorder (insulin resistant) and inflammation, in terms of improving the composition of intestinal flora and modulating metabolic pathway factors in relevant tissues. The present work strongly elucidated the potential mechanism of sinensetin in improving metabolic disorders and supported the contribution of sinensetin to health benefits, thus offering a better perspective in understanding the role played by sinensetin in human health.
川陈皮素是柑橘类水果中最常见的多酚之一，最近因其预防或治疗疾病的能力而受到广泛研究。本文综述了川陈皮素及其衍生物的生物利用度的相关文献，并评估了其对人类代谢综合征的潜在改善作用。川陈皮素及其衍生物主要聚集在大肠，并通过肠道微生物群（GM）和肝脏进行广泛代谢。因此，肠道微生物对川陈皮素的吸收和代谢有显著影响。有趣的是，不仅GM作用于川陈皮素使其代谢，川陈皮素还调节GM的组成。因此，川陈皮素在血液和尿液中代谢为甲基、葡萄糖醛酸和硫酸盐代谢物。此外，据报道，川陈皮素在改善肠道菌群组成和调节相关组织中的代谢途径因子方面，具有改善代谢综合征的有益作用，包括脂质代谢紊乱（肥胖、非酒精性脂肪性肝病、动脉粥样硬化）、葡萄糖代谢紊乱（胰岛素抵抗）和炎症。本研究有力地阐明了川陈皮素改善代谢紊乱的潜在机制，并支持了川陈皮素对健康有益的作用，从而为理解川陈皮素在人类健康中的作用提供了更好的视角。
