Raptor 在淋巴细胞分化和功能中的作用。
The role of Raptor in lymphocytes differentiation and function.
机构信息
Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States.
出版信息
Front Immunol. 2023 May 22;14:1146628. doi: 10.3389/fimmu.2023.1146628. eCollection 2023.
Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.
Raptor 是 mTORC1 的关键组成部分，它对于招募底物到 mTORC1 并促进其亚细胞定位是必需的。Raptor 具有高度保守的 N 端结构域和七个 WD40 重复序列，这些结构域与 mTOR 和其他 mTORC1 相关蛋白相互作用。mTORC1 参与多种细胞事件，并介导分化和代谢。许多因素直接或间接地介导了淋巴细胞的分化和功能，这对于免疫至关重要。在这篇综述中，我们总结了 Raptor 在淋巴细胞分化和功能中的作用，Raptor 通过调节细胞因子的分泌来诱导早期淋巴细胞代谢、发育、增殖和迁移。此外，Raptor 通过调节淋巴细胞的稳态维持和激活来调节其功能。
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