Macfarlane S D, Tauro G P, Rendall K, Welch J J, Ekert H
Am J Hematol. 1986 Aug;22(4):403-7. doi: 10.1002/ajh.2830220409.
A technique for examining relatively large volumes of bone marrow for involvement by malignancy is described. The use of discontinuous Percoll gradients offers no advantage over conventional methods in the diagnosis of hematological malignancy. Its usefulness in detecting infiltration by solid tumor is uncertain. Complete exclusion of malignancy from the fraction containing hematologic stem cells in three patients raises the possibility that this technique is a useful adjunct to other methods of marrow purging before autologous marrow rescue in malignant disease.
本文描述了一种用于检查相对大量骨髓是否存在恶性肿瘤累及的技术。在血液系统恶性肿瘤的诊断中，使用不连续的 Percoll 梯度法相较于传统方法并无优势。其在检测实体瘤浸润方面的实用性尚不确定。在三名患者中，从含有造血干细胞的部分完全排除恶性肿瘤，这增加了一种可能性，即该技术在恶性疾病自体骨髓挽救前的其他骨髓净化方法中是一种有用的辅助手段。
