平均近亲繁殖还是平衡近亲繁殖？
Average inbreeding or equilibrium inbreeding?
作者信息
Hedrick P W
出版信息
Am J Hum Genet. 1986 Jun;38(6):965-70.
Abstract
The equilibrium inbreeding is always higher than the average inbreeding. For human populations with high inbreeding levels, the inbreeding equilibrium is more than 25% higher than the average inbreeding. Assuming no initial inbreeding in the population, the equilibrium inbreeding value is closely approached in 10 generations or less. A secondary effect of this higher inbreeding level is that the equilibrium frequency of recessive detrimental alleles is somewhat lower than expected using average inbreeding.
摘要
平衡近亲繁殖系数总是高于平均近亲繁殖系数。对于近亲繁殖水平较高的人群，平衡近亲繁殖系数比平均近亲繁殖系数高出25%以上。假设群体中初始无近亲繁殖，在10代或更少的世代中就会接近平衡近亲繁殖值。这种较高近亲繁殖水平的一个次要影响是，隐性有害等位基因的平衡频率略低于使用平均近亲繁殖系数时的预期值。
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