Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes (LEAMER), Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Chemical Engineering Processes and Forest Products Research Centre (CIEPQPF), Department of Chemical Engineering, University of Coimbra, Coimbra, Portugal.
Future Microbiol. 2023 Nov;18:1049-1059. doi: 10.2217/fmb-2022-0202. Epub 2023 Jun 7.
species are human pathogens that are resistant to almost all antifungals currently available in clinical practice. The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate chelates containing Cu(II), Mn(II) and Ag(I) against , , and were evaluated. To different degrees, all of the test chelates inhibited the viability of planktonic conidial cells, displaying MICs ranging from 0.029 to 72.08 μM. Generally, Mn(II)-containing chelates were the least toxic to lung epithelial cells, particularly [Mn(oda)(phen)(HO)][Mn(oda)(phen)(oda)].4HO (MICs: 1.62-3.25 μM: selectivity indexes >64). Moreover, this manganese-based chelate reduced the biofilm biomass formation and diminished the mature biofilm viability. [Mn(oda)(phen)(HO)][Mn(oda)(phen)(oda)].4HO opens a new chemotherapeutic avenue for the deactivation of these emergent, multidrug-resistant filamentous fungi.
这些物种是对目前临床应用的几乎所有抗真菌药物都具有耐药性的人类病原体。评估了 16 种含有 Cu(II)、Mn(II)和 Ag(I)的 1,10-菲啰啉（phen）/1,10-菲啰啉-5,6-二酮/二羧酸配合物对 、 、 和 的作用。所有测试配合物在不同程度上均抑制浮游游动孢子细胞的活力，显示 MIC 值范围为 0.029 至 72.08 μM。一般来说，含 Mn(II)的配合物对肺上皮细胞的毒性最小，特别是 [Mn(oda)(phen)(HO)][Mn(oda)(phen)(oda)].4HO（MICs：1.62-3.25 μM：选择性指数>64）。此外，这种基于锰的配合物减少了生物膜生物量的形成并降低了成熟生物膜的活力。[Mn(oda)(phen)(HO)][Mn(oda)(phen)(oda)].4HO 为这些新兴的、多药耐药丝状真菌的失活开辟了新的化学治疗途径。
