Kozeny G A, Ragona B P, Bansal V K, Hurley R M, Dixon D W, Vertuno L L, Hano J E
Am J Med. 1986 Jun;80(6):1184-6. doi: 10.1016/0002-9343(86)90682-0.
Abrupt withdrawal of calcium channel blocking agents has been associated with symptoms of ischemic heart disease, but acute myocardial infarction has not been noted. Herein is described a severely uremic patient who had an acute myocardial infarction shortly after discontinuance of diltiazem, although results of subsequent coronary arteriography were normal. It is postulated that myocardial damage occurred because of increased intracellular calcium flux, augmented myocardial contractility, and/or drug withdrawal-related coronary spasm.
钙通道阻滞剂突然停药与缺血性心脏病症状有关，但尚未见急性心肌梗死的报道。本文描述了一名严重尿毒症患者，在停用地尔硫䓬后不久发生急性心肌梗死，尽管随后的冠状动脉造影结果正常。据推测，心肌损伤是由于细胞内钙通量增加、心肌收缩力增强和/或与停药相关的冠状动脉痉挛所致。
