Warren J S, Ward P A
Am J Med Sci. 1986 Aug;292(2):97-103. doi: 10.1097/00000441-198608000-00006.
In recent years, increasing clinical and experimental data have provided compelling evidence that neutrophil-derived oxygen radicals and their metabolites are important mediators of vascular endothelial injury. In this review, attention is directed toward in vitro, ex vivo, and in vivo experimental studies contributing to current understanding of mechanisms of oxyradical mediated endothelial damage. Although these studies may have broad significance, they appear to have particular relevance to the pathogenesis of the adult respiratory distress syndrome and other types of acute pulmonary dysfunction.
近年来，越来越多的临床和实验数据提供了令人信服的证据，表明中性粒细胞衍生的氧自由基及其代谢产物是血管内皮损伤的重要介质。在这篇综述中，我们将关注有助于当前对氧自由基介导的内皮损伤机制理解的体外、离体和体内实验研究。尽管这些研究可能具有广泛的意义，但它们似乎与成人呼吸窘迫综合征和其他类型的急性肺功能障碍的发病机制特别相关。
