Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China.
Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China.
Biomed Pharmacother. 2023 Aug;164:114981. doi: 10.1016/j.biopha.2023.114981. Epub 2023 Jun 7.
Lipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating lipid profiles and related metabolic processes, including lipid synthesis, catabolism, absorption, transport, and peroxidation. Even wild-type mice show augmented lipid metabolism after treatment with celastrol. This review aims to provide an overview of recent advancements in the lipid-regulating properties of celastrol, as well as to elucidate its underlying molecular mechanisms. Besides, potential strategies for targeted drug delivery and combination therapy are proposed to enhance the lipid-regulating effects of celastrol and avoid the limitations of its clinical application.
脂代谢紊乱在各种与脂质相关的疾病的发生发展中起着关键作用，如肥胖、动脉粥样硬化、非酒精性脂肪肝、2 型糖尿病和癌症。从雷公藤中提取的生物活性化合物雷公藤红素最近显示出对脂质代谢紊乱具有强大的调节作用，并对脂质相关疾病具有有前景的治疗效果。有大量证据表明，雷公藤红素可以通过调节脂质谱和相关代谢过程，包括脂质合成、分解代谢、吸收、转运和过氧化，来改善脂代谢紊乱。甚至野生型小鼠在接受雷公藤红素治疗后也表现出增强的脂质代谢。本综述旨在概述雷公藤红素在调节脂质代谢方面的最新进展，并阐明其潜在的分子机制。此外，还提出了靶向药物传递和联合治疗的潜在策略，以增强雷公藤红素的脂质调节作用并避免其临床应用的局限性。
