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植物次生代谢产物对妇科癌症的先天预防作用:炎症反应与治疗作用。

The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic action.

机构信息

Department of Chemistry, GLA University, Mathura, Uttar Pradesh 281406, India.

Cayman Health, CTMH Doctors Hospital in Cayman Islands, George Town, Grand Cayman, USA.

出版信息

Biochim Biophys Acta Rev Cancer. 2023 Jul;1878(4):188929. doi: 10.1016/j.bbcan.2023.188929. Epub 2023 Jun 5.

Abstract

Gynecologic cancers can make up the bulk of cancers in both humans and animals. The stage of diagnosis and the type of tumor, its origin, and its spread are a few of the factors that influence how effectively a treatment modality works. Currently, radiotherapy, chemotherapy, and surgery are the major treatment options recommended for the eradication of malignancies. The use of several anti-carcinogenic drugs increases the chance of harmful side effects, and patients might not react to the treatments as expected. The significance of the relationship between inflammation and cancer has been underscored by recent research. As a result, it has been shown that a variety of phytochemicals with beneficial bioactive effects on inflammatory pathways have the potential to act as anti-carcinogenic medications for the treatment of gynecologic cancer. The current paper reviews the significance of inflammatory pathways in gynecologic malignancies and discusses the role of plants-derived secondary metabolites that are useful in the treatment of cancer.

摘要

妇科癌症可在人类和动物的癌症中占很大比例。诊断阶段、肿瘤类型、起源及其扩散是影响治疗方式有效性的几个因素。目前,放疗、化疗和手术是推荐用于消除恶性肿瘤的主要治疗方法。使用多种抗癌药物会增加产生有害副作用的机会,并且患者的反应可能不如预期。最近的研究强调了炎症与癌症之间关系的重要性。因此,已经表明,具有有益的抗炎途径生物活性的多种植物化学物质有可能作为治疗妇科癌症的抗癌药物。本文综述了炎症途径在妇科恶性肿瘤中的意义,并讨论了植物来源的次生代谢产物在癌症治疗中的作用。

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