Renner R P, Lee M, Andors L, McNamara T F, Brook S
Oral Surg Oral Med Oral Pathol. 1979 Apr;47(4):323-8. doi: 10.1016/0030-4220(79)90254-8.
Denture stomatitis is an erythematous disorder of the denture-bearing tissues, especially the maxillary hard palate. Frequently it mimics many oral lesions. Early diagnosis of the lesion is essential to assure rational therapy. A diagnostic procedure based upon the enumeration of Candida albicans appeared to be feasible. A control group of twenty fully dentate subjects with no clinical evidence of stomatitis was sampled to establish normal concentrations of C. albicans in the oral flora. Samples were taken from a triangular area of the hard palate, serially diluted in broth, and all dilutions were incubated aerobically. In the control population, C. albicans never exceeded 100 organisms per square centimeter per subject sample. A population of edentulous patients with denture stomatitis, prior to any therapy, was similarly sampled. In many of these patients the concentration of C. albicans always exceeded 10,000 organisms per square centimeter per patient. The patients received denture replacements and antimycotic antibiotic therapy. Follow-up cultures were taken 4 to 6 weeks after completion of therapy. All patients were found to be free of denture stomatitis.
义齿性口炎是义齿承托组织尤其是上颌硬腭的一种红斑性疾病。它常与许多口腔病变相似。对该病变进行早期诊断对于确保合理治疗至关重要。一种基于白色念珠菌计数的诊断方法似乎是可行的。选取了20名无口炎临床证据的全口牙齿受试者作为对照组，以确定口腔菌群中白色念珠菌的正常浓度。从硬腭的一个三角形区域取样，在肉汤中进行连续稀释，所有稀释液进行需氧培养。在对照组人群中，每位受试者样本每平方厘米白色念珠菌数量从未超过100个。对一组患义齿性口炎的无牙患者在进行任何治疗前进行了类似取样。在这些患者中，许多患者每平方厘米白色念珠菌浓度始终超过10000个。患者接受了义齿更换和抗真菌抗生素治疗。治疗完成后4至6周进行随访培养。发现所有患者均无义齿性口炎。
