Fradin Delphine, Tost Jorg, Busato Florence, Mille Clémence, Lachaux Fanny, Deleuze Jean-François, Apter Gisèle, Benachi Alexandra
INSERM U1169, Bicêtre Hospital, Paris Sud University, Le Kremlin-Bicêtre, Paris, France.
The Laboratory for Epigenetics and Environment, Centre National de Recherche en Genomique Humaine, CEA-Institut de Biologie Francois Jacob, Université Paris-Saclay, Evry, France.
Front Cell Dev Biol. 2023 May 22;11:1185311. doi: 10.3389/fcell.2023.1185311. eCollection 2023.
Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an epigenetic mechanism that regulates gene expression and contributes to adaptive phenotypic variations, we investigated methylation changes in maternal blood of a longitudinal cohort of pregnant women from the first trimester of gestation to the third. Interestingly, during pregnancy, we found a gain of methylation in genes involved in morphogenesis, such as ezrin, while we identified a loss of methylation in genes promoting maternal-infant bonding ( and ). Together, our results provide insights into the biological mechanisms underlying physiological adaptations during pregnancy.
怀孕是一种具有多种生理适应性的状态。由于DNA甲基化是一种调节基因表达并导致适应性表型变异的表观遗传机制，我们对一组从妊娠早期到晚期的孕妇纵向队列的母血中的甲基化变化进行了研究。有趣的是，在怀孕期间，我们发现参与形态发生的基因（如埃兹蛋白）存在甲基化增加，而促进母婴联结的基因则存在甲基化减少。总之，我们的结果为孕期生理适应的生物学机制提供了见解。
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