Zhang Guokai, Liu Zhenying, Li Zihan, Zhang Bing, Yao Pengyu, Qiao Yun
Binzhou Hospital of Traditional Chinese Medicine, Binzhou, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Front Genet. 2023 May 23;14:1182363. doi: 10.3389/fgene.2023.1182363. eCollection 2023.
Osteoporosis (OP) is a metabolic disease that affects bone, resulting in a progressive decrease in bone mass, quality, and micro-architectural degeneration. Natural products have become popular for managing OP in recent years due to their minimal adverse side effects and suitability for prolonged use compared to chemically synthesized products. These natural products are known to modulate multiple OP-related gene expressions, making epigenetics an important tool for optimal therapeutic development. In this study, we investigated the role of epigenetics in OP and reviewed existing research on using natural products for OP management. Our analysis identified around twenty natural products involved in epigenetics-based OP modulation, and we discussed potential mechanisms. These findings highlight the clinical significance of natural products and their potential as novel anti-OP therapeutics.
骨质疏松症（OP）是一种影响骨骼的代谢性疾病，会导致骨量逐渐减少、骨质下降以及微结构退变。近年来，天然产物因其副作用极小且与化学合成产品相比更适合长期使用，在管理骨质疏松症方面变得越来越受欢迎。已知这些天然产物可调节多个与骨质疏松症相关的基因表达，这使得表观遗传学成为优化治疗开发的重要工具。在本研究中，我们调查了表观遗传学在骨质疏松症中的作用，并回顾了使用天然产物管理骨质疏松症的现有研究。我们的分析确定了约二十种参与基于表观遗传学的骨质疏松症调节的天然产物，并讨论了潜在机制。这些发现突出了天然产物的临床意义及其作为新型抗骨质疏松症治疗药物的潜力。
