Meza-Alvarado J C, Page R A, Mallard B, Bromhead C, Palmer B R
School of Health Sciences, Massey University, Wellington, New Zealand.
Front Cardiovasc Med. 2023 May 23;10:1190513. doi: 10.3389/fcvm.2023.1190513. eCollection 2023.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Currently, cardiovascular disease risk algorithms play a role in primary prevention. However, this is complicated by a lack of powerfully predictive biomarkers that could be observed in individuals before the onset of overt symptoms. A key potential biomarker for heart disease is the vascular endothelial growth factor (VEGF-A), a molecule that plays a pivotal role in blood vessel formation. This molecule has a complex biological role in the cardiovascular system due to the processes it influences, and its production is impacted by various CVD risk factors. Research in different populations has shown single nucleotide polymorphisms (SNPs) may affect circulating VEGF-A plasma levels, with some variants associated with the development of CVDs, as well as CVD risk factors. This minireview aims to give an overview of the VEGF family, and of the SNPs reported to influence VEGF-A levels, cardiovascular disease, and other risk factors used in CVD risk assessments.
心血管疾病（CVDs）是全球首要死因。目前，心血管疾病风险算法在一级预防中发挥作用。然而，由于缺乏在明显症状出现之前就能在个体中观察到的强大预测生物标志物，情况变得复杂。心脏病的一个关键潜在生物标志物是血管内皮生长因子（VEGF - A），它是一种在血管形成中起关键作用的分子。由于它所影响的过程，该分子在心血管系统中具有复杂的生物学作用，其产生受到多种心血管疾病风险因素的影响。针对不同人群的研究表明，单核苷酸多态性（SNPs）可能会影响循环VEGF - A血浆水平，一些变体与心血管疾病的发生以及心血管疾病风险因素相关。本综述旨在概述VEGF家族，以及据报道会影响VEGF - A水平、心血管疾病和用于心血管疾病风险评估的其他风险因素的单核苷酸多态性。
