State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Oral Dis. 2024 May;30(4):1806-1817. doi: 10.1111/odi.14642. Epub 2023 Jun 8.
Inflammaging and immunosenescence are characteristics of senescent immune system alterations. This review provides insights into inflammaging and immunosenescence in periodontitis and focuses on the innerlink of inflammaging and immunosenescence in alveolar bone turnover from a perspective of cell-cell interaction.
This review is conducted by a narrative approach to discuss the effect of inflammaging and immunosenescence in aging-related alveolar bone loss. A comprehensive literature research in PubMed and Google was applied to identify reports in English.
Inflammaging is concerned with abnormal M1 polarization and increasing circulating inflammatory cytokines, while immunosenescence involves reduced infection and vaccine responses, depressed antimicrobial function, and infiltration of aged B cells and memory T cells. TLR-mediated inflammaging and altered adaptive immunity significantly affect alveolar bone turnover and aggravate aging-related alveolar bone loss. Besides, energy consumption also plays a vital role in aged immune and skeletal system of periodontitis.
Senescent immune system exerts a significant function in aging-related alveolar bone loss. Inflammaging and immunosenescence interact functionally and mechanistically, which affects alveolar bone turnover. Therefore, further clinical treatment strategies targeting alveolar bone loss could be based on the specific molecular mechanism connecting inflammaging, immunosenescence, and alveolar bone turnover.
炎症和免疫衰老都是衰老免疫系统改变的特征。本综述深入探讨了牙周炎中的炎症和免疫衰老，并从细胞间相互作用的角度关注了炎症和免疫衰老在牙槽骨代谢中的内在联系。
采用叙述性方法，讨论炎症和免疫衰老在与年龄相关的牙槽骨丢失中的作用。通过在 PubMed 和 Google 上进行全面的文献检索，以英文报告为目标进行研究。
炎症涉及异常的 M1 极化和循环炎症细胞因子的增加，而免疫衰老则涉及感染和疫苗反应减少、抗菌功能下降、衰老 B 细胞和记忆 T 细胞浸润。TLR 介导的炎症和适应性免疫改变显著影响牙槽骨代谢，加重与年龄相关的牙槽骨丢失。此外，能量消耗在牙周炎中衰老的免疫和骨骼系统中也起着至关重要的作用。
衰老的免疫系统在与年龄相关的牙槽骨丢失中起着重要作用。炎症和免疫衰老在功能和机制上相互作用，影响牙槽骨代谢。因此，针对牙槽骨丢失的进一步临床治疗策略可以基于连接炎症、免疫衰老和牙槽骨代谢的特定分子机制。
