运动介导前列腺癌中肌动蛋白的释放和肿瘤抑制，且独立于雄激素信号传导。
Exercise Mediates Myokine Release and Tumor Suppression in Prostate Cancer Independent of Androgen Signaling.
作者信息
Kim Jin-Soo, Taaffe Dennis R, Galvão Daniel A, Saad Fred, Newton Robert U
机构信息
Department of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
出版信息
Exerc Sport Sci Rev. 2023 Oct 1;51(4):161-168. doi: 10.1249/JES.0000000000000323. Epub 2023 Jun 7.
A prominent toxicity of androgen suppression in patients with prostate cancer (PCa) is loss of skeletal muscle. Exercise may induce tumor suppression through the endocrinal function of skeletal muscle; however, this is currently unknown. In this review, we summarize our work demonstrating the acute and chronic myokine response to exercise and the tumor-suppressive effect of circulatory milieu alteration in PCa patients.
前列腺癌（PCa）患者雄激素抑制的一个突出毒性是骨骼肌流失。运动可能通过骨骼肌的内分泌功能诱导肿瘤抑制；然而，目前尚不清楚。在这篇综述中，我们总结了我们的工作，展示了对运动的急性和慢性肌动蛋白反应以及PCa患者循环环境改变的肿瘤抑制作用。
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