Institute of Biomedical Sciences, Shanxi University, Taiyuan, 030006, China.
Breast Cancer Res Treat. 2023 Aug;200(3):305-321. doi: 10.1007/s10549-023-06995-z. Epub 2023 Jun 8.
Breast cancer (BC) is a complex disease with various subtypes and genetic alterations that impact DNA repair pathways. Understanding these pathways is essential for developing effective treatments and improving patient outcomes.
This study investigates the significance of DNA repair pathways in breast cancer, specifically focusing on various pathways such as nucleotide excision repair, base excision repair, mismatch repair, homologous recombination repair, non-homologous end joining, fanconi anemia pathway, translesion synthesis, direct repair, and DNA damage tolerance. The study also examines the role of these pathways in breast cancer resistance and explores their potential as targets for cancer treatment.
Recent advances in targeted therapies have shown promise in exploiting DNA repair pathways for BC treatment. However, much research is needed to improve the efficacy of these therapies and identify new targets. Additionally, personalized treatments that target specific DNA repair pathways based on tumor subtype or genetic profile are being developed. Advances in genomics and imaging technologies can potentially improve patient stratification and identify biomarkers of treatment response. However, many challenges remain, including toxicity, resistance, and the need for more personalized treatments. Continued research and development in this field could significantly improve BC treatment.
乳腺癌（BC）是一种复杂的疾病，具有多种亚型和遗传改变，这些改变会影响 DNA 修复途径。了解这些途径对于开发有效的治疗方法和改善患者的预后至关重要。
本研究探讨了 DNA 修复途径在乳腺癌中的意义，特别是关注核苷酸切除修复、碱基切除修复、错配修复、同源重组修复、非同源末端连接、范可尼贫血途径、跨损伤合成、直接修复和 DNA 损伤耐受等各种途径。本研究还研究了这些途径在乳腺癌耐药中的作用，并探讨了它们作为癌症治疗靶点的潜力。
靶向治疗的最新进展表明，利用 DNA 修复途径治疗 BC 具有一定的前景。然而，为了提高这些疗法的疗效并确定新的靶点，还需要进行大量的研究。此外，正在开发基于肿瘤亚型或遗传特征针对特定 DNA 修复途径的个体化治疗方法。基因组学和成像技术的进步可能会提高患者的分层能力，并识别治疗反应的生物标志物。然而，仍存在许多挑战，包括毒性、耐药性以及对更个体化治疗的需求。该领域的持续研究和开发可能会显著改善 BC 的治疗效果。
