Barbara Davis Center for Diabetes, Division of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Division of Pediatric Endocrinology and Diabetology, Herman B Wells Center for Pediatric Research; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
J Clin Endocrinol Metab. 2023 Nov 17;108(12):3067-3079. doi: 10.1210/clinem/dgad328.
A diagnosis of type 1 diabetes (T1D) and the subsequent requirement for exogenous insulin treatment is associated with considerable acute and chronic morbidity and a substantial effect on patient quality of life. Importantly, a large body of work suggests that early identification of presymptomatic T1D can accurately predict clinical disease, and when paired with education and monitoring, can yield improved health outcomes. Furthermore, a growing cadre of effective disease-modifying therapies provides the potential to alter the natural history of early stages of T1D. In this mini review, we highlight prior work that has led to the current landscape of T1D screening and prevention, as well as challenges and next steps moving into the future of these rapidly evolving areas of patient care.
诊断为 1 型糖尿病（T1D）并随后需要外源性胰岛素治疗与相当大的急性和慢性发病率以及对患者生活质量的重大影响有关。重要的是，大量研究表明，早期识别无症状 T1D 可以准确预测临床疾病，并且与教育和监测相结合，可以改善健康结果。此外，越来越多的有效疾病修饰疗法为改变 T1D 早期阶段的自然病史提供了潜力。在这篇迷你综述中，我们强调了导致当前 T1D 筛查和预防现状的先前工作，以及在这些快速发展的患者护理领域中未来面临的挑战和下一步措施。
