Faculty of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
Interv Cardiol Clin. 2023 Jul;12(3):367-380. doi: 10.1016/j.iccl.2023.02.003. Epub 2023 Mar 15.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a late complication of acute pulmonary thromboembolism owing to incomplete clot dissolution in pulmonary artery. Pulmonary endarterectomy is the first-line treatment for CTEPH. However, 40% of patients are not candidates for surgery because of distal lesions or age. Balloon pulmonary angioplasty (BPA), a catheter-based intervention, is increasingly being used worldwide for treating inoperable CTEPH. Previous BPA strategy had a major concern of reperfusion pulmonary edema as a complication. However, recent refined strategies promise safe and effective BPA. Five-year survival rate after BPA is 90% for inoperable CTEPH, comparable with that of operable CTEPH.
慢性血栓栓塞性肺动脉高压(CTEPH)是急性肺血栓栓塞症的一种晚期并发症,由于肺动脉内血栓不完全溶解所致。肺动脉内膜切除术是 CTEPH 的一线治疗方法。然而,由于存在远端病变或年龄等因素,40%的患者不适合手术。球囊肺动脉成形术(BPA)作为一种基于导管的介入治疗方法,在全球范围内越来越多地用于治疗无法手术的 CTEPH。以前的 BPA 策略主要关注再灌注肺水肿作为一种并发症。然而,最近的改良策略保证了 BPA 的安全性和有效性。对于无法手术的 CTEPH,BPA 后的 5 年生存率为 90%,与可手术的 CTEPH 相当。