Department of Internal Medicine, One Brooklyn Health/Brookdale University Hospital and Medical Center, Brooklyn, New York, USA.
Department of Internal Medicine, North Mississippi Medical Center, Tupelo, Mississippi, USA.
Eur J Haematol. 2023 Sep;111(3):432-440. doi: 10.1111/ejh.14024. Epub 2023 Jun 8.
There is a paucity of data on the outcomes of coronavirus disease 2019 (COVID-19) in patients with sickle cell disease (SCD) in the United States. We examined the outcomes of patients with COVID-19 and SCD.
We utilized the National Inpatient Sample (NIS) to identify the data of patients diagnosed with COVID-19 and SCD in 2020 using the International Classification of Disease, Tenth Revision codes. In-hospital outcomes (invasive mechanical ventilation and mortality) were compared between SCD and non-SCD groups.
Of the 1 057 550 COVID-19 hospitalizations, 2870 (0.3%) had SCD. The median age of the SCD group was 42 (IQR: 31) vs. 66 (IQR: 23) in the non-SCD group (p < .0001). Patients with SCD were likely to be females (62.02% vs. 37.98%, p < .0001), Blacks (87.81% vs. 12.19%, p < .0001), and in the lowest income quartile (50.62% vs. 11.15%, p < .0001). There was no difference in the outcomes between the two groups. There were increased odds of invasive mechanical ventilation and in-hospital mortality in COVID-19 in Asians, Hispanics, Native Americans, and Blacks (except for in-hospital mortality) compared to Whites.
In-hospital mortality and invasive mechanical ventilation outcomes in SCD are comparable to that in non-SCD patients hospitalized with COVID-19.
在美国，关于冠状病毒病 2019（COVID-19）患者镰状细胞病（SCD）结局的数据很少。我们研究了 COVID-19 和 SCD 患者的结局。
我们利用国家住院患者样本（NIS），使用国际疾病分类，第十次修订版代码，确定 2020 年诊断为 COVID-19 和 SCD 的患者的数据。比较 SCD 和非 SCD 组的住院期间结局（有创机械通气和死亡率）。
在 1057550 例 COVID-19 住院患者中，有 2870 例（0.3%）患有 SCD。SCD 组的中位年龄为 42（IQR：31），而非 SCD 组为 66（IQR：23）（p<0.0001）。SCD 患者更可能为女性（62.02% vs. 37.98%，p<0.0001）、黑人（87.81% vs. 12.19%，p<0.0001）和收入最低的四分位数（50.62% vs. 11.15%，p<0.0001）。两组之间的结局没有差异。与白人相比，亚洲人、西班牙裔、美国原住民和黑人（除了住院死亡率外）的 COVID-19 患者有创机械通气和住院死亡率的可能性更高。
COVID-19 住院的 SCD 患者的住院死亡率和有创机械通气结局与非 SCD 患者相当。
